Protein markers tied to chemotherapy success
Doctors in Shanghai have screened two protein markers to determine pancreatic cancer patients' sensitivity to chemotherapy, which may rewrite current treatment guidelines and improve patients' overall survival rate.
The team of researchers from Shanghai Ruijin Hospital said on Monday that the results of the study have been validated in three groups at home and abroad, showing strong clinical applicability.
A paper about the study was published as the cover article in the top international medical journal Nature Medicine on March 19.
More than 330,000 people die from pancreatic cancer worldwide each year, with an overall five-year survival rate of approximately 6 percent, according to the hospital.
By analyzing the data of 191 patients over more than three years of follow-ups, the researchers constructed a prognostic prediction model for pancreatic cancer, and identified two protein markers — NDUFB8 and CEMIP2 — which are able to accurately predict patients' sensitivity to chemotherapy.
Results of the study were independently verified among people with pancreatic cancer in and around Paris, France, and at Fudan University Shanghai Cancer Center and Shanghai Changhai Hospital.
"The research answered one of the two main queries that are current bottlenecks in the field of pancreatic cancer treatment: Which patients are sensitive to chemotherapy and which chemotherapy drugs are they sensitive to?" said Shen Baiyong, a professor at the Pancreatic Disease Diagnosis and Treatment Center of Ruijin Hospital and a leading researcher on the team.
Related articles
What's next for Iran after death of its president in crash?
JERUSALEM (AP) — The death of Iran’s president is unlikely to lead to any immediate changes in Iran’2024-05-21- Lando Norris became the youngest-ever British driver when he made his debut at 19-years-old in the 22024-05-21
Can I get my private pension at 55 due to this bizarre birth year quirk? STEVE WEBB replies
I've had some advice from my private pension provider, which said I was in the unusual position of b2024-05-21Nigerian journalist's arrest last week triggers criticism of worsening press freedoms
ABUJA, Nigeria (AP) — A Nigerian journalist’s arrest last week has triggered criticism of worsening2024-05-21Young Boys seals 6th Swiss soccer league title in 7 years after rallying from firing coach Wicky
GENEVA (AP) — Young Boys sealed its sixth Swiss league title in seven years by winning at Servette 12024-05-21Tom Brady roast: Netflix live event features Robert Kraft and Bill Belichick reunion
INGLEWOOD, Calif. (AP) — Three months before Tom Brady gets roasted by critics as Fox Sports’ top NF2024-05-21
atest comment